Executive Director of Research, St. Boniface Hospital

Professor, Dept. Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba

The research focus is on control mechanisms of gene expression in heart failure, and in particular cardiac fibrosis. A key finding is the critical importance of the transcription factor scleraxis, which is required for cardiac fibrosis to occur following pressure overload. Scleraxis directly regulates the expression of numerous fibrosis-related genes.